A rare synaptonemal complex protein 3 gene variant in unexplained female infertility

Synaptonemal Complex Protein 3 Transcript Analysis in Breast Cancer

BACKGROUND Breast cancer is the most frequent cancer in women. Cancer/Testis antigens are immunogenic proteins ectopically expressed in human neoplasms. Synaptonemal complex protein 3 (SYCP3) belongs to cancer/testis genes family involved in meiotic events and spermatogenesis. The aim of this study was to express analysis of SYCP3 in breast cancer and validate it as a breast cancer biomarker. ...

Unexplained Infertility

Dexamethasone in unexplained infertility.

OBJECTIVE To determine if dexamethasone could be a suitable option in the treatment of patients with unexplained infertility. METHODS This study was carried out in the Obstetrics Department of Amir University Hospital, Semnan, Iran, from April 2001 to May 2008. One hundred and twenty-four cases of unexplained infertility that underwent ovulation induction and intrauterine insemination (IUI) (...

P-223: Analysis of Synaptonemal Complex Gene Disorders Involving in Recurrent Spontaneous Abortion

Background: Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Maternally age, previous spontaneous abortion, prolonged ovulation to implantation, Gravidity, Interval Prolonged time to pregnancy, Balanced chromosomal translocations and Genetic disorders. The aim of this study was t...

Synaptonemal Complex Protein 3 Is a Prognostic Marker in Cervical Cancer

Synaptonemal complex protein 3 (SCP3), a member of Cor1 family, is up-regulated in various cancer cells; however, its oncogenic potential and clinical significance has not yet been characterized. In the present study, we investigated the oncogenic role of SCP3 and its relationship with phosphorylated AKT (pAKT) in cervical neoplasias. The functional role of SCP3 expression was investigated by o...